Professor Brandon Wainwright

Group Leader, Genomics of Development and Disease Division

Affiliate Professor of Institute for Molecular Bioscience

Institute for Molecular Bioscience

b.wainwright@imb.uq.edu.au

Highlights

Professor Brandon Wainwright AM is a geneticist, renowned for discovering the genetic pathway that causes most human cancer. He is skilled in molecular genetics, where he is using genetic approaches to dig through DNA and find the genes that cause disease.

He commenced using these skills to locate the cystic fibrosis gene, but it was when isolating a gene responsible for a rare form of brain cancer called Medulloblastoma, that he discovered the ‘Hedgehog Pathway.'

He discovered not only the first brain cancer-causing gene but also a pathway involved in most cancers of all types.

The primary focus of his current research is brain cancer because it is the most common cause of death in children and the most common cause of cancer-related death in people under 40. He is also applying his expertise to common cancer generally (particularly skin cancer), and neurodegenerative disease.

Success for Professor Wainwright will be seeing a child cured of brain cancer that would otherwise have died. And he is confident that he can help make it happen.

He is formerly Director of UQ's Institute for Molecular Bioscience, where he proudly leads a team of talented discovery scientists translating their findings to life-changing applications.

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Wainwright Research Group: Cancer and cell signalling

Researcher biography

Professor Brandon Wainwright AM is Co-Director of the Children's Brain Cancer Centre and leads a laboratory within the UQ Diamantina Institute focused on understanding the genetic pathways behind medulloblastoma, a type of brain tumour that occurs predominantly in children. He is Chair of the European Molecular Biology Laboratory (EMBL) Australia, Chair of the Advisory Board of the Robinson Research Institute and Chair of the Board of the South Australian Immunogenomics Cancer Institute (SAIGENCI), and serves on the boards the Australian Genome Research Facility as well as several national and international scientific review committees, including the MRFF Brain Tumour Roadmap Committee.

Professor Wainwright completed his undergraduate and postgraduate studies at The University of Adelaide, after which he secured a postdoctoral fellowship with St Mary's Hospital at Imperial College London. During his six years at Imperial he worked on the first human genome project and also became a Medical Research Council Senior Research Fellow. He returned to Australia in 1990 to join UQ's Centre for Molecular and Cellular Biology (now IMB) and led the Institute for Molecular Biology until 2019.

Professor Wainwright is a geneticist, renowned for discovering the genetic pathway that causes most human cancer. He is skilled in molecular genetics, where he is using genetic approaches to dig through DNA and find the genes that cause disease. He commenced using these skills to locate the cystic fibrosis gene, but it was when isolating a gene responsible for a rare form of brain cancer called Medulloblastoma, that he discovered the role of the 'Hedgehog Pathway' in common human cancer.

Featured projects	Duration
Tissue repair and cancer

Publications

Journal Articles (139)

Conference Papers (17)

Journal Articles

Gilbertson, Richard J., Behjati, Sam, Böttcher, Anna-Lisa, Bronner, Marianne E., Burridge, Matthew, Clausing, Henrick, Clifford, Harry, Danaher, Tracey, Donovan, Laura K., Drost, Jarno, Eggermont, Alexander M.M., Emerson, Chris, Flores, Mona G., Hamerlik, Petra, Jabado, Nada, Jones, Andrew, Kaessmann, Henrick, Kleinman, Claudia L., Kool, Marcel, Kutscher, Lena M., Lindberg, Gavin, Linnane, Emily, Marioni, John C., Maris, John M., Monje, Michelle, Macaskill, Alexandra, Niederer, Steven, Northcott, Paul A., Peeters, Elizabeth ... Pfister, Stefan M. (2024). The Virtual Child. Cancer Discovery, 14 (4), 663-668. doi: 10.1158/2159-8290.cd-23-1500

Endersby, Raelene, Wainwright, Brandon J. and Gottardo, Nicholas G. (2023). Editorial: Bench to bedside: translating pre-clinical research into clinical trials for childhood brain tumors. Frontiers in Oncology, 13 1274465. doi: 10.3389/fonc.2023.1274465

Kojic, Marija, Maybury, Mellissa K., Waddell, Nicola, Koufariotis, Lambros T., Addala, Venkateswar, Millar, Amanda, Wood, Scott, Pearson, John V., Hansford, Jordan R., Hassall, Tim and Wainwright, Brandon J. (2023). Efficient detection and monitoring of pediatric brain malignancies with liquid biopsy based on patient-specific somatic mutation screening. Neuro-Oncology, 25 (8), 1507-1517. doi: 10.1093/neuonc/noad032

Garcia-Lopez, Jesus, Ahmad, Shiekh Tanveer, Li, Yiran, Gudenas, Brian, Kojic, Marija, Manz, Friedrik, Jonchere, Barbara, Mayasundari, Anand, Pitre, Aaron, Hadley, Jennifer, Paul, Leena, Batts, Melissa, Pfister, Stefan, Waszak, Sebastian, Bianski, Brandon, Tinkle, Christopher, Orr, Brent, Rankovic, Zoran, Robinson, Giles, Wainwright, Brandon, Kutscher, Lena, Lin, Hong and Northcott, Paul (2023). MDB-23. ELP1 GERMLINE DEFICIENCY SENSITIZES THE GRANULE NEURON LINEAGE TO SHH MEDULLOBLASTOMA AND EXPOSES NOVEL THERAPEUTIC VULNERABILITIES. Neuro-Oncology, 25 (Supplement_1), i67-i67. doi: 10.1093/neuonc/noad073.255

Vo, Tuan, Balderson, Brad, Jones, Kahli, Ni, Guiyan, Crawford, Joanna, Millar, Amanda, Tolson, Elissa, Singleton, Matthew, Kojic, Marija, Robertson, Thomas, Walters, Shaun, Mulay, Onkar, Bhuva, Dharmesh D., Davis, Melissa J., Wainwright, Brandon J., Nguyen, Quan and Genovesi, Laura A. (2023). Spatial transcriptomic analysis of Sonic hedgehog medulloblastoma identifies that the loss of heterogeneity and promotion of differentiation underlies the response to CDK4/6 inhibition. Genome Medicine, 15 (1) 29, 29. doi: 10.1186/s13073-023-01185-4

Kojic, Marija, Abbassi, Nour E. H., Lin, Ting-Yu, Jones, Alun, Wakeling, Emma L., Clement, Emma, Nakou, Vasiliki, Singleton, Matthew, Dobosz, Dominika, Kaliakatsos, Marios, Glatt, Sebastian and Wainwright, Brandon J. (2023). A novel ELP1 mutation impairs the function of the Elongator complex and causes a severe neurodevelopmental phenotype. Journal of Human Genetics, 68 (7), 445-453. doi: 10.1038/s10038-023-01135-3

Gaik, Monika, Kojic, Marija, Wainwright, Brandon J and Glatt, Sebastian (2023). Elongator and the role of its subcomplexes in human diseases. EMBO Molecular Medicine, 15 (2) e16418, e16418. doi: 10.15252/emmm.202216418

Gaik, Monika, Kojic, Marija, Stegeman, Megan R., Öncü‐Öner, Tülay, Kościelniak, Anna, Jones, Alun, Mohamed, Ahmed, Chau, Pak Yan Stefanie, Sharmin, Sazia, Chramiec‐Głąbik, Andrzej, Indyka, Paulina, Rawski, Michał, Biela, Anna, Dobosz, Dominika, Millar, Amanda, Chau, Vann, Ünalp, Aycan, Piper, Michael, Bellingham, Mark C., Eichler, Evan E., Nickerson, Deborah A., Güleryüz, Handan, Abbassi, Nour El Hana, Jazgar, Konrad, Davis, Melissa J., Mercimek‐Andrews, Saadet, Cingöz, Sultan, Wainwright, Brandon J. and Glatt, Sebastian (2022). Functional divergence of the two Elongator subcomplexes during neurodevelopment. EMBO Molecular Medicine, 14 (7) e15608, e15608. doi: 10.15252/emmm.202115608

Adolphe, Christelle, Millar, Amanda, Kojic, Marija, Barkauskas, Deborah S., Sundstrom, Anders, Swartling, Fredrik J., Hediyeh-zadeh, Soroor, Tan, Chin Wee, Davis, Melissa J., Genovesi, Laura A. and Wainwright, Brandon J. (2021). SOX9 defines distinct populations of cells in SHH medulloblastoma but is not required for Math1-driven tumour formation. Molecular Cancer Research, 19 (11), 1831-1839. doi: 10.1158/1541-7786.mcr-21-0117

Guo, Duancheng, Wang, Yuan, Cheng, Yan, Liao, Shengyou, Hu, Jian, Du, Fang, Xu, Gang, Liu, Yongqiang, Cai, Kathy Q., Cheung, Martin, Wainwright, Brandon J., Lu, Q. Richard, Zhao, Yi and Yang, Zeng-jie (2021). Tumor cells generate astrocyte-like cells that contribute to SHH-driven medulloblastoma relapse. Journal of Experimental Medicine, 218 (9) e20202350, 1-18. doi: 10.1084/jem.20202350

Genovesi, Laura A., Millar, Amanda, Tolson, Elissa, Singleton, Matthew, Hassall, Emily, Kojic, Marija, Brighi, Caterina, Girard, Emily, Andradas, Clara, Kuchibhotla, Mani, Bhuva, Dharmesh D., Endersby, Raelene, Gottardo, Nicholas G., Bernard, Anne, Adolphe, Christelle, Olson, James M., Taylor, Michael D., Davis, Melissa J. and Wainwright, Brandon J. (2021). Systems pharmacogenomics identifies novel targets and clinically actionable therapeutics for medulloblastoma. Genome Medicine, 13 (1) 103, 103. doi: 10.1186/s13073-021-00920-z

Kojic, Marija, Gawda, Tomasz, Gaik, Monika, Begg, Alexander, Salerno-Kochan, Anna, Kurniawan, Nyoman D., Jones, Alun, Drożdżyk, Katarzyna, Kościelniak, Anna, Chramiec-Głąbik, Andrzej, Hediyeh-Zadeh, Soroor, Kasherman, Maria, Shim, Woo Jun, Sinniah, Enakshi, Genovesi, Laura A., Abrahamsen, Rannvá K., Fenger, Christina D., Madsen, Camilla G., Cohen, Julie S., Fatemi, Ali, Stark, Zornitza, Lunke, Sebastian, Lee, Joy, Hansen, Jonas K., Boxill, Martin F., Keren, Boris, Marey, Isabelle, Saenz, Margarita S., Brown, Kathleen ... Wainwright, Brandon J. (2021). Elp2 mutations perturb the epitranscriptome and lead to a complex neurodevelopmental phenotype. Nature Communications, 12 (1) 2678, 2678. doi: 10.1038/s41467-021-22888-5

Starobova, Hana, Monteleone, Mercedes, Adolphe, Christelle, Batoon, Lena, Sandrock, Cheyenne J., Tay, Bryan, Deuis, Jennifer R., Smith, Alexandra V., Mueller, Alexander, Nadar, Evelyn Israel, Lawrence, Grace Pamo, Mayor, Amanda, Tolson, Elissa, Levesque, Jean-Pierre, Pettit, Allison R., Wainwright, Brandon J., Schroder, Kate and Vetter, Irina (2021). Vincristine-induced peripheral neuropathy is driven by canonical NLRP3 activation and IL-1β release. Journal of Experimental Medicine, 218 (5) e20201452. doi: 10.1084/jem.20201452

Adolphe, Christelle, Xue, Angli, Fard, Atefeh Taherian, Genovesi, Laura A., Yang, Jian and Wainwright, Brandon J. (2021). Genetic and functional interaction network analysis reveals global enrichment of regulatory T cell genes influencing basal cell carcinoma susceptibility. Genome Medicine, 13 (1) 19, 19. doi: 10.1186/s13073-021-00827-9

Genovesi, Laura A., Puttick, Simon, Millar, Amanda, Kojic, Marija, Ji, Pengxiang, Lagendijk, Anne K., Brighi, Caterina, Bonder, Claudine S, Adolphe, Christelle and Wainwright, Brandon J. (2020). Patient derived orthotopic xenograft models of Medulloblastoma lack a functional blood brain barrier. Neuro-Oncology, 23 (5), 732-742. doi: 10.1093/neuonc/noaa266

Villani, Rehan, Sim, Seen Ling, Roy, Edwige, Wainwright, Brandon, Francois, Mathias and Khosrotehrani, Kiarash (2020). Ectopic expression of SOX18 in Basal cell carcinoma negatively regulates tumour progression. Journal of Dermatological Science, 98 (3), 179-185. doi: 10.1016/j.jdermsci.2020.04.006

Fraser, James, Essebier, Alexandra, Brown, Alexander S., Davila, Raul Ayala, Harkins, Danyon, Zalucki, Oressia, Shapiro, Lauren P., Penzes, Peter, Wainwright, Brandon J., Scott, Matthew P., Gronostajski, Richard M., Bodén, Mikael, Piper, Michael and Harvey, Tracey J. (2019). Common Regulatory Targets of NFIA, NFIX and NFIB during Postnatal Cerebellar Development. Cerebellum, 19 (1), 89-101. doi: 10.1007/s12311-019-01089-3

Robson, Jonathan P., Remke, Marc, Kool, Marcel, Julian, Elaine, Korshunov, Andrey, Pfister, Stefan M., Osborne, Geoffrey W., Taylor, Michael D., Wainwright, Brandon and Reynolds, Brent A. (2019). Identification of CD24 as a marker of Patched1 deleted medulloblastoma-initiating neural progenitor cells. PLoS ONE, 14 (1) e0210665, e0210665. doi: 10.1371/journal.pone.0210665

Fraser, James, Essebier, Alexandra, Brown, Alexander S., Davila, Raul Ayala, Sengar, Ameet S., Tu, YuShan, Ensbey, Kathleen S., Day, Bryan W., Scott, Matthew P., Gronostajski, Richard M., Wainwright, Brandon J., Boden, Mikael, Harvey, Tracey J. and Piper, Michael (2018). Granule neuron precursor cell proliferation is regulated by NFIX and intersectin 1 during postnatal cerebellar development. Brain Structure and Function, 224 (2), 811-827. doi: 10.1007/s00429-018-1801-3

Kojic, Marija, Gaik, Monika, Kiska, Bence, Salerno-Kochan, Anna, Hunt, Sarah, Tedoldi, Angelo, Mureev, Sergey, Jones, Alun, Whittle, Belinda, Genovesi, Laura A., Adolphe, Christelle, Brown, Darren L., Stow, Jennifer L., Alexandrov, Kirill, Sah, Pankaj, Glatt, Sebastian and Wainwright, Brandon J. (2018). Elongator mutation in mice induces neurodegeneration and ataxia-like behavior. Nature Communications, 9 (1) 3195, 3195. doi: 10.1038/s41467-018-05765-6

Sheybani-Deloui, Sepideh, Chi, Lijun, Staite, Marian V., Cain, Jason E., Nieman, Brain J., Henkelman, R. Mark, Wainwright, Brandon J., Potter, S. Steven, Bagli, Darius J., Lorenzo, Armando J. and Rosenblum, Norman D. (2017). Activated Hedgehog-GLI Signaling Causes Congenital Ureteropelvic Junction Obstruction. Journal of the American Society of Nephrology : JASN, 29 (2), 532-544. doi: 10.1681/ASN.2017050482

Conduit, S. E., Ramaswamy, V., Remke, M., Watkins, D. N., Wainwright, B. J., Taylor, M. D., Mitchell, C. A. and Dyson, J. M. (2017). A compartmentalized phosphoinositide signaling axis at cilia is regulated by INPP5E to maintain cilia and promote Sonic Hedgehog medulloblastoma. Oncogene, 36 (43), 5969-5984. doi: 10.1038/onc.2017.208

Sangar, Michelle L. Cook, Genovesi, Laura A., Nakamoto, Madison W., Davis, Melissa J., Knobluagh, Sue E., Ji, Pengxiang, Millar, Amanda, Wainwright, Brandon J. and Olson, James M. (2017). Inhibition of CDK4/6 by palbociclib significantly extends survival in medulloblastoma patient-derived xenograft mouse models. Clinical Cancer Research, 23 (19), 5802-5813. doi: 10.1158/1078-0432.CCR-16-2943

Ho, Uda Y. and Wainwright, Brandon J. (2017). Patched1 patterns fibroblast growth factor 10 and forkhead box F1 expression during pulmonary branch formation. Mechanisms of Development, 147, 37-48. doi: 10.1016/j.mod.2017.09.001

Casas, Bárbara S., Adolphe, Christelle, Lois, Pablo, Navarrete, Nelson, Solís, Natalia, Bustamante, Eva, Gac, Patricio, Cabané, Patricio, Gallegos, Ivan, Wainwright, Brandon J. and Palma, Verónica (2017). Downregulation of the Sonic Hedgehog/Gli pathway transcriptional target Neogenin-1 is associated with basal cell carcinoma aggressiveness. Oncotarget, 8 (48), 84006-84018. doi: 10.18632/oncotarget.21061

Kojic, Marija and Wainwright, Brandon (2016). The many faces of elongator in neurodevelopment and disease. Frontiers in Molecular Neuroscience, 9 (NOV2016) 115, 115. doi: 10.3389/fnmol.2016.00115

Constantin, Lena, Constantin, Myrna and Wainwright, Brandon J. (2016). MicroRNA biogenesis and hedgehog-patched signaling cooperate to regulate an important developmental transition in granule cell development. Genetics, 202 (3), 1105-1118. doi: 10.1534/genetics.115.184176

Fraser, James, Essebier, Alexandra, Gronostajski, Richard M., Boden, Mikael, Wainwright, Brandon J., Harvey, Tracey J. and Piper, Michael (2016). Cell-type-specific expression of NFIX in the developing and adult cerebellum. Brain Structure and Function, 222 (5), 1-20. doi: 10.1007/s00429-016-1340-8

Adolphe, Christelle, Junker, Jan Phillipp, Lyubimova, Anna, van Oudenaarden, Alexander and Wainwright, Brandon (2016). Patched receptors sense, interpret and establish an epidermal Hedgehog signalling gradient. Journal of Investigative Dermatology, 137 (1), 179-186. doi: 10.1016/j.jid.2016.06.632

Harris, Lachlan, Genovesi, Laura A., Gronostajski, Richard M., Wainwright, Brandon J. and Piper, Michael (2015). Nuclear factor one transcription factors: divergent functions in developmental versus adult stem cell populations. Developmental Dynamics, 244 (3), 227-238. doi: 10.1002/dvdy.24182

Constantin, Lena and Wainwright, Brandon J. (2015). MicroRNAs promote granule cell expansion in the cerebellum through Gli2. Cerebellum, 14 (6), 688-698. doi: 10.1007/s12311-015-0672-x

Palmer, Colin J., Galan-Caridad, Jose M., Weisberg, Stuart P., Lei, Liang, Esquilin, Jose M., Croft, Gist F., Wainwright, Brandon, Canoll, Peter, Owens, David M. and Reizis, Boris (2014). Zfx facilitates tumorigenesis caused by activation of the hedgehog pathway. Cancer Research, 74 (20), 5914-5924. doi: 10.1158/0008-5472.CAN-14-0834

Adolphe, Christelle, Nieuwenhuis, Erica, Villani, Rehan, Li, Zhu Juan, Kaur, Pritinder, Hui, Chi-chung and Wainwright, Brandon J. (2014). Patched 1 and Patched 2 redundancy has a key role in regulating epidermal differentiation. Journal of Investigative Dermatology, 134 (7), 1981-1990. doi: 10.1038/jid.2014.63

Milla, Luis A., Arros, Andrea, Espinoza, Natalie, Remke. Marc, Kool, Marcel, Taylor, Michael D., Pfister, Stefan M., Wainwright, Brandon J. and Palma, Verónica (2014). Neogenin1 is a Sonic Hedgehog target in medulloblastoma and is necessary for cell cycle progression. International Journal of Cancer, 134 (1), 21-31. doi: 10.1002/ijc.28330

Genovesi, Laura A., Ng, Ching Ging, Davis, Melissa J., Remke, Marc, Taylor, Michael D., Adams, David J., Rust, Alistair G., Ward, Jerrold M., Ban, Kenneth H., Jenkins, Nancy A., Copeland, Neal G. and Wainwright, Brandon J. (2013). Sleeping Beauty mutagenesis in a mouse medulloblastoma model defines networks that discriminate between human molecular subgroups. Proceedings of the National Academy of Sciences of the United States of America, 110 (46), E4325-E4334. doi: 10.1073/pnas.1318639110

Calao, M., Sekyere, E. O., Cui, H. J., Cheung, B. B., Thomas, W. D., Keating, J., Chen, J. B., Raif, A., Jankowski, K., Davies, N. P., Bekkum, M. V., Chen, B., Tan, O., Ellis, T., Norris, M. D., Haber, M., Kim. E. S., Shohet, J. M., Trahair, T. N., Lui, T., Wainwright, B. J., Ding, H. F. and Marshall, G. M. (2013). Direct effects of Bmi1 on p53 protein stability inactivates oncoprotein stress responses in embryonal cancer precursor cells at tumor initiation. Oncogene, 32 (31), 3616-3626. doi: 10.1038/onc.2012.368

Metzis, Vicki, Courtney, Andrew D., Kerr, Markus C., Ferguson, Charles, Rondón Galeano, Maria C., Parton, Robert G., Wainwright, Brandon J. and Wicking, Carol (2013). Patched1 is required in neural crest cells for the prevention of orofacial clefts. Human Molecular Genetics, Advance Access (24) ddt353, 1-10. doi: 10.1093/hmg/ddt353

Martinez, Constanza, Hugo Cornejo, Victor, Lois, Pablo, Ellis, Tammy, Solis, Natalia P., Wainwright, Brandon J. and Palma, Veronica (2013). Proliferation of Murine Midbrain Neural Stem Cells Depends upon an Endogenous Sonic Hedgehog (Shh) Source. PLoS One, 8 (6) e65818, e65818.1-e65818.10. doi: 10.1371/journal.pone.0065818

Villani, Rehan M., Waters, Michael J. and Wainwright, Brandon J. (2013). Murine basal cell carcinoma leads to tumor mediated alterations in endocrine lgf1 signaling. Endocrine - Related Cancer, 20 (3), 273-281. doi: 10.1530/ERC-12-0307

Li, Zhu Juan, Nieuwenhuis, Erica, Nien, Weilun, Zhang, Xiaoyun, Zhang, Jennifer, Puviindran, Vijitha, Wainwright, Brandon J., Kim, Peter C. W. and Hui, Chi-chung (2012). Kif7 regulates Gli2 through Sufu-dependent and -independent functions during skin development and tumorigenesis. Development, 139 (22), 4152-4161. doi: 10.1242/dev.081190

Lee, Michelle J., Hatton, Beryl A., Villavicencio, Elisabeth H., Khanna, Paritosh C., Friedman, Seth D., Ditzler, Sally, Pullar, Barbara, Robison, Keith, White, Kerry F., Tunkey, Chris, LeBlanc, Michael, Randolph-Habecker, Julie, Knoblaugh, Sue E., Hansen, Stacey, Richards, Andrew, Wainwright, Brandon J., McGovern, Karen and Olson, James M. (2012). Hedgehog pathway inhibitor saridegib (IPI-926) increases lifespan in a mouse medulloblastoma model. Proceedings of the National Academy of Sciences of the United States of America, 109 (20), 7859-7864. doi: 10.1073/pnas.1114718109

Ashe, Alyson, Butterfield, Natalie C., Town, Liam, Courtney, Andrew D., Cooper, Ashley N., Ferguson, Charles, Barry, Rachael, Olsson, Fredrik, Liem, Karel F., Parton, Robert G., Wainwright, Brandon J., Anderson, Kathryn V., Whitelaw, Emma and Wicking, Carol (2012). Mutations in mouse Ift144 model the craniofacial, limb and rib defects in skeletal ciliopathies. Human Molecular Genetics, 21 (8) ddr613, 1808-1823. doi: 10.1093/hmg/ddr613

Ngan, Elly Sau-Wai, Garcia-Barcelo, Maria-Merce, Yip, Benjamin Hon-Kei, Poon, Hiu-Cheng, Lau, Sin-Ting, Kwok, Carmen Ka-Man, Sat, Eric, Sham, Mai-Har, Wong, Kenneth Kak-Yuen, Wainwright, Brandon J., Cherny, Stacey S, Hui, Chi-Chung, Sham, Pak Chung, Lui, Vincent Chi-Hang and Tam, Paul Kwong-Ham (2011). Hedgehog/Notch-induced premature gliogenesis represents a new disease mechanism for Hirschsprung disease in mice and humans. Journal of Clinical Investigation, 121 (9), 3467-3478. doi: 10.1172/JCI43737

Fan, Qipeng, Gu, Dongsheng, He, Miao, Liu, Hailan, Sheng. Tao, Xie, Guorui, Li, Ching-xin, Zhang, Xaoili, Wainwright, Brandon J., Garrossian, Arash, Garrossian, Massoud, Gardner, Dale and Xie, Jingwu (2011). Tumor shrinkage by cyclopamine tartrate through inhibiting hedgehog signaling. Chinese Journal of Cancer, 30 (7), 472-481. doi: 10.5732/cjc.011.10157

Dave, Richa K., Ellis, Tammy, Toumpas, Melissa C., Robson, Jonathan P., Julian, Elaine, Adolphe, Christelle, Bartlett, Perry F., Cooper, Helen M., Reynolds, Brent A. and Wainwright, Brandon J. (2011). Sonic hedgehog and notch signaling can cooperate to regulate neurogenic divisions of neocortical progenitors. PLoS One, 6 (2) e14680, e14680-1-e14680-13. doi: 10.1371/journal.pone.0014680

Shikata, Yayoi, Okada, Toshiaki, Hashimoto, Mitsuhiro, Ellis, Tammy L., Matsumaru, Daisuke, Shiroishi, Toshihiko, Ogawa, Masaharu, Wainwright, Brandon J. and Motoyama, Jun (2011). Ptch1-mediated dosage-dependent action of Shh signaling regulates neural progenitor development at late gestational stages. Developmental Biology, 349 (2), 147-159. doi: 10.1016/j.ydbio.2010.10.014

MacDonald, Kelli P. A., Palmer, James S., Cronau, Stephen, Seppanen, Elke Jane, Olver, Stuart, Raffelt, Neil C., Kuns, Rachel, Pettit, Allison R., Clouston, Andrew, Wainwright, Brandon J., Branstetter, Dan, Smith, Jeffrey, Paxton, Raymond J., Cerretti, Douglas Pat, Bonham, Lynn, Hill, Geoffrey R. and Hume, David A. (2010). An antibody against the colony-stimulating factor 1 receptor (CSF1R) depletes the resident subset of monocytes and tissue and tumor-associated macrophages but does not inhibit inflammation. Blood, 116 (19), 3955-3963. doi: 10.1182/blood-2010-02-266296

Julian, Elaine, Hallahan, Andrew R. and Wainwright, Brandon J. (2010). RBP-J is not required for granule neuron progenitor development and medulloblastoma initiated by Hedgehog pathway activation in the external germinal layer. Neural Development, 5 (1) 27, 27. doi: 10.1186/1749-8104-5-27

Villani, Rehan M., Adolphe, Christelle, Palmer, James, Waters, Michael J. and Wainwright, Brandon J. (2010). Patched1 inhibits epidermal progenitor cell expansion and basal cell carcinoma formation by limiting Igfbp2 activity. Cancer Prevention Research, 3 (10), 1222-1234. doi: 10.1158/1940-6207.CAPR-10-0082

Julian, E., Dave, R. K., Robson, J. P., Hallahan, A. R. and Wainwright, B. J. (2010). Canonical Notch signaling is not required for the growth of Hedgehog pathway-induced medulloblastoma. Oncogene, 29 (24), 3465-3476. doi: 10.1038/onc.2010.101

Hudson, T. J., Anderson, W., Aretz, A., Barker, A. D., Grimmond, S. M., Pearson, J. V., Cloonan, N., Gardiner, B. A., Waddell, N. J., Wilson, P. J., Wainwright, B. J. and The International Cancer Genome Consortium (2010). International network of cancer genome projects. Nature, 464 (7291), 993-998. doi: 10.1038/nature08987

Sousa, Kyle M., Villaescusa, J. Carlos, Cajanek, Lukas, Ondr, Jennifer K., Castelo-Branco, Goncalo, Hofstra, Wytske, Bryja, Vitezslav, Palmberg, Carina, Bergman, Tomas, Wainwright, Brandon, Lang, Richard A. and Arenas, Ernest (2010). Wnt2 regulates progenitor proliferation in the developing ventral midbrain. Journal of Biological Chemistry, 285 (10), 7246-7253. doi: 10.1074/jbc.M109.079822

Butterfield, N. C., Metzis, V, McGlinn, E, Bruce, S. J., Wainwright, B. J. and Wicking, C (2009). Patched 1 is a crucial determinant of asymmetry and digit number in the vertebrate limb. DEVELOPMENT, 136 (20), 3515-3524. doi: 10.1242/dev.037507

Siggins, S. L., Nguyen, N. Y. N., McCormack, M. P., Vasudevan, S, Villani, R, Jane, S. M., Wainwright, B. J. and Curtis, D. J. (2009). The hedgehog receptor Patched1 regulates myeloid and lymphoid progenitors by distinct cell-extrinsic mechanisms. BLOOD, 114 (5), 995-1004. doi: 10.1182/blood-2009-03-208330

Moraes, R. C., Chang, H, Harrington, N, Landua, J. D., Prigge, J. T., Lane, T. F., Wainwright, B. J., Hamel, P. A. and Lewis, M. T. (2009). Ptch1 is required locally for mammary gland morphogenesis and systemically for ductal elongation. DEVELOPMENT, 136 (9), 1423-1432. doi: 10.1242/dev.023994

Thomas, W. D., Chen, J, Gao, Y. R., Cheung, B, Koach, J, Sekyere, E, Norris, M. D., Haber, M, Ellis, T, Wainwright, B and Marshall, G. M. (2009). Patched1 deletion increases N-Myc protein stability as a mechanism of medulloblastoma initiation and progression. ONCOGENE, 28 (13), 1605-1615. doi: 10.1038/onc.2009.3

Smart, Chanel E., Clarke, Catherine, Brooks, Kelly M., Raghavendra, Ashwini, Brewster, Brooke L., French, Juliet D., Hetherington, Rehan, Fleming, Jean S., Rothnagel, Joseph A., Wainwright, Brandon, Lakhani, Sunil R. and Brown, Melissa A. (2008). Targeted disruption of Brca1 in restricted compartments of the mouse mammary epithelia. Breast Cancer Research and Treatment, 112 (2), 237-241. doi: 10.1007/s10549-007-9859-2

Yang, Zeng-Jie, Ellis, Tammy L., Markant, Shirley L., Read, Tracy-Ann, Kessler, Jessica D, Melissa Bourboulas, Schuller, Ulrich, Machold, Robert, Fishell, Gord, Rowitch, David H., Wainwright, Brandon J. and Wechsler-Reya, Robert J. (2008). Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells. Cancer Cell, 14 (2), 135-145. doi: 10.1016/j.ccr.2008.07.003

McGlinn, Edwina, Richman, Joy M., Metzis, Vicki, Town, Liam, Butterfield, Natalie C., Wainwright, Brandon J. and Wicking, Carol (2008). Expression of the NET family member Zfp503 is regulated by hedgehog and BMP signaling in the limb. Developmental Dynamics, 237 (4), 1172-1182. doi: 10.1002/dvdy.21508

Ingram, W. J., McCue, K. I., Tran, T. H., Hallahan, A. R. and Wainwright, B. J. (2008). Sonic Hedgehog regulates Hes1 through a novel mechanism that is independent of canonical Notch pathway signalling. Oncogene, 27 (10), 1489-1500. doi: 10.1038/sj.onc.1210767

Hilliard, Tom N., Zhu, Jie, Farley, Ray, Escudero-Garcia, Sara, Wainwright, Brandon J., Jeffery, Peter K., Griesenbach, Uta, Bush, Andrew, Davies, Jane C. and Alton, Eric W. F. W. (2008). Nasal abnormalities in cystic fibrosis mice independent of infection and inflammation. American Journal of Respiratory Cell and Molecular Biology, 39 (1), 19-25. doi: 10.1165/rcmb.2007-0284OC

McMorran, Brendan J., Patat, Severine A. Ouvry, Carlin, John B., Grimwood, Keith, Jones, Alun, Armstrong, David S., Galati, John C., Cooper, Peter J., Byrnes, Catherine A., Francis, Paul W., Robertson, Colin F., Hume, David A., Borchers, Christoph H., Wainwright, Claire E. and Wainwright, Brandon J. (2007). Novel neutrophil-derived proteins in bronchoalveolar lavage fluid indicate an exaggerated inflammatory response in pediatric cystic fibrosis patients. Clinical Chemistry, 53 (10), 1782-1791. doi: 10.1373/clinchem.2007.087650

Scott-Ward, T. S., Cai, Z. W., Dawson, E. S., Doherty, A., Da Paula, A. C., Davidson, H., Porteous, D. J., Wainwright, B. J., Amaral, M. D., Sheppard, D. N. and Boyd, A. C. (2007). Chimeric constructs endow the human CFTR Cl(-)channel with the gating behavior of murine CFTR. Proceedings of The National Academy of Sciences of The United States of America, 104 (41), 16365-16370. doi: 10.1073/pnas.0701562104

Wang, H., Gilner, J. B., Bautch, V. L., Wang, D. Z., Wainwright, B. J., Kirby, S. L. and Patterson, C. (2007). Wnt2 coordinates the commitment of mesoderm to hematopoietic, endothelial, and cardiac lineages in embryoid bodies. Journal of Biological Chemistry, 282 (1), 782-791. doi: 10.1074/jbc.M606610200

Ferrari, S., Griesenbach, U., Iida, A., Farley, R., Wright, A. M., Zhu, J., Munkonge, F. M., Smith, S. N., You, J., Ban, H., Inoue, M., Chan, M., Singh, C., Verdon, B., Argent, B. E., Wainwright, B., Jeffery, P. K., Geddes, D. M., Porteous, D. J., Hyde, S. C., Gray, M. A., Hasegawa, M. and Alton, E. W. F. W. (2007). Sendai virus-mediated CFTR gene transfer to the airway epithelium. Gene Therapy, 14 (19), 1371-1379. doi: 10.1038/sj.gt.3302991

Kunzelmann, Karl, Scheidt, Kerstin, Scharf, Birgit, Ousingsawat, Jiraporn, Schreiber, Rainer, Wainwright, Brandon and McMorran, Brendan (2006). Flagellin of Pseudomonas aeruginosa inhibits Na+ transport in airway epithelia. Faseb Journal, 20 (3), 545-546. doi: 10.1096/fj.05-4454fje

Adolphe, Christelle, Hetherington, Rehan, Ellis, Tammy and Wainwright, Brandon (2006). Patched1 functions as a gatekeeper by promoting cell cycle progression. Cancer Research, 66 (4), 2081-2088. doi: 10.1158/0008-5472.CAN-05-2146

McGlinn, Edwina, Lammerts van Bueren, Kelly, Fiorenza, Salvatore, Mo, Rong, Poh, Alisa M., Forrest, Alistair, Soares, Marcelo Bento, Bonaldo, Maria de Fatima, Grimmond, Sean, Hui, Chi-chung, Wainwright, Brandon and Wicking, Carol (2005). Pax9 and Jagged1 act downstream of Gli3 in vertabrate limb development. Mechanisms of Development, 122 (11), 1218-1233. doi: 10.1016/j.mod.2005.06.012

Marsh, A., Wicking, C. A., Wainwright, B. J. and Chenevix-Trench, G. (2005). DHPLC analysis of patients with nevoid basal cell carcinoma syndrome reveals novel PTCH missense mutations in the serol-sensing domain. Human Mutation, 26 (3), 283-293. doi: 10.1002/humu.9365

Adolphe, C. M. and Wainwright, B. J. (2005). Pathways to improving skin regeneration. Expert Reviews in Molecular Medicine, 7 (20), 1-14. doi: 10.1017/S1462399405009890

Taylor, Michael D., Zhang, Xiaoyun, Liu, Ling, Hui, Chi-Chung, Mainprize, Todd G., Scherer, Stephen W., Wainwright, Brandon, Hogg, David and Rutka, James T. (2004). Failure of a medulloblastoma-derived mutant of SUFU to suppress WNT signaling. Oncogene, 23 (26), 4577-4583. doi: 10.1038/sj.onc.1207605

Hime, G. R., Lada, H., Fietz, M. J., Gillies, S., Passmore, A., Wicking, C. A. and Wainwright, B. J. (2004). Functional analysis in Drosophila indicates that the NBCCS/PTCH1 mutation G509V results in activation of smoothened through a dominant-negative mechanism. Developmental Dynamics, 229 (4), 780-790. doi: 10.1002/dvdy.10499

Smyth, Ian, Ellis, Tammy, Hetherington, Rehan, Riley, Emily, Narang, Monica, Mahony, Donna, Wicking, Carol, Rothnagel, Joseph A. and Wainwright, Brandon J. (2004). Krt6a-Cre transgenic mice direct LoxP-mediated recombination to the companion cell layer of the hair follicle and following induction by retinoic acid to the interfollicular epidermis. Journal of Investigative Dermatology, 122 (1), 232-234. doi: 10.1046/j.0022-202X.2003.22122.x

Adolphe, C., Narang, M., Ellis, T., Wicking, C., Kaur, P. and Wainwright, B. (2004). An in vivo comparative study of sonic, desert and Indian hedgehog reveals that hedgehog pathway activity regulates epidermal stem cell homeostasis. Development, 131 (20), 5009-5019. doi: 10.1242/dev.01367

McMorran, B., Town, L., Costelloe, E., Palmer, J., Engel, J., Hume, D. and Wainwright, B. (2003). Effector ExoU from the type III secretion system is an important modulator of gene expression in lung epithelial cells in response to Pseudomonas aeruginosa infection. Infection And Immunity, 71 (10), 6035-6044. doi: 10.1128/IAI.71.10.6035-6044.2003

Wells, C. A., Ravasi, T., Faulkner, G. J., Carninci, P., Okazaki, Y., Hayashizaki, Y., Sweet, M.J., Wainwright, B. J. and Hume, D. A. (2003). Genetic control of the innate immune response. BMC Immunology, 4 (Article 5) 5, 1-18. doi: 10.1186/1471-2172-4-5

Oceandy, D., McMorran, B., Schreiber, R., Wainwright, B. J. and Kunzelmann, K. (2003). GFP-tagged CFTR transgene is functional in the G551D cystic fibrosis mouse colon. Journal of Membrane Biology, 192 (3), 159-167. doi: 10.1007/s00232-002-1072-y

Ellis, Tammy, Smyth, Ian, Riley, Emily, Bowles, Josephine, Adolphe, Christelle, Rothnagel, Joseph A., Wicking, Carol and Wainwright, Brandon J. (2003). Overexpression of sonic hedgehog suppresses embryonic hair follicle morphogenesis. Developmental Biology, 263 (2), 203-215. doi: 10.1016/S0012-1606(03)00394-4

Ellis, Tammy, Smyth, Ian, Riley, Emily, Graham, Scott, Elliot, Kate, Narang, Monica, Kay, Graham F., Wicking, Carol and Wainwright, Brandon (2003). Patched 1 conditional null allele in mice. Genesis, 36 (3), 158-161. doi: 10.1002/gene.10208

Sasmono, R. T., Oceandy, D., Pollard, J. W., Tong, W., Pavli, P., Wainwright, B. J., Ostrowski, M. C., Himes, S. R. and Hume, D. A. (2003). A macrophage colony-stimulating factor receptor-green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse. Blood, 101 (3), 1155-1163. doi: 10.1182/blood-2002-02-1569

Evans, T. M., Ferguson, C., Wainwright, B. J., Parton, R. G. and Wicking, C. (2003). Rab23, a negative regulator of hedgehog signaling, localizes to the plasma membrane and the endocytic pathway. Traffic, 4 (12), 869-884. doi: 10.1046/j.1600-0854.2003.00141.x

Oceandy, Delvac, McMorran, Brendan J., Smith, Stephen N., Schreiber, Rainer, Kunzelmann, Karl, Alton, Eric W. F. W., Hume, David A. and Wainwright, Brandon J. (2002). Gene complementation of airway epithelium in the cystic fibrosis mouse is necessary and sufficient to correct the pathogen clearance and inflammatory abnormalities. Human Molecular Genetics, 11 (9), 1059-1067. doi: 10.1093/hmg/11.9.1059

Ingram, W. J., Wicking, C. A., Grimmond, S. M., Forrest, A. R. and Wainwright, B. J. (2002). Novel genes regulated by Sonic Hedgehog in pluripotent mesenchymal cells. Oncogene, 21 (53), 8196-8205. doi: 10.1038/sj.onc.1205975

Taylor, M. D., Liu, L., Raffel, C., Hui, C. C., Mainprize, T. G., Zhang, X. Y., Agatep, R., Chiappa, S., Gao, L. Z., Lowrance, A., Hao, A. H., Goldstein, A. M., Stavrou, T., Scherer, S. W., Dura, W. T., Wainwright, B., Squire, J. A., Rutka, J. T. and Hogg, D. (2002). Mutations in SUFU predispose to medulloblastoma. Nature Genetics, 31 (3), 306-310. doi: 10.1038/ng916

Ravasi, T., Wells, C., Forrest, A., Walsh, N., Underhill, D. M., Wainwright, B. J., Aderem, A., Grimmond, S. and Hume, D. A. (2002). Generation of Diversity in the Innate Immune System: Macrophage Heterogeneity Arises From Gene-Autonomous Transcriptional Probability of Individual Inducible Genes. Journal of Immunology, 168 (1), 44-50. doi: 10.4049/jimmunol.168.1.44

Mcmorran, B., Palmer, J., Lunn, D., Oceandy, D., Costelloe, E. O., Thomas, G., Hume, D. A. and Wainwright, B. J. (2001). G551D CF mice display an abnormal host response and have impaired clearance of Pseudomonas lung disease. AJP-Lung Cellular and Molecular Physiology, 281 (3), 740-747. doi: 10.1152/ajplung.2001.281.3.L740

Evans, T, Poh, A, Webb, C, Wainwright, B, Wicking, C, Glass, I, Carey, WF and Fietz, M (2001). Novel mutation in the Delta 7-dehydrocholesterol reductase gene in an Australian patient with Smith-Lemli-Opitz syndrome. American Journal of Medical Genetics, 103 (4), 344-347. doi: 10.1002/ajmg.1573

Ferrari, S., Kitson, C., Farley, R., Steel, R., Marriott, C., Parkins, D. A., Scarpa, M., Wainwright, B., Evans, M. J., Colledge, W. H., Geddes, D. M. and Alton, E. W. F. W. (2001). Mucus altering agents as adjuncts for nonviral gene transfer to airway epithelium. Gene Therapy, 8 (18), 1380-1386. doi: 10.1038/sj.gt.3301525

Valverde, Miguel A., Vázquez, Esther, Muñoz, Francisco J., Nobles, Muriel, Delaney, Stephen J., Wainwright, Brandon J., Colledge, William H. and Sheppard, David N. (2000). Murine CFTR channel and its role in regulatory volume decrease of small intestine crypts. Cellular Physiology and Biochemistry, 10 (5-6), 321-328. doi: 10.1159/000016365

Evans, T, Boonchai, W, Shanley, S, Smyth, I, Gillies, S, Georgas, K, Wainwright, B, Chenevix-Trench, G and Wicking, C (2000). The spectrum of patched mutations in a collection of Australian basal cell carcinomas. Human Mutation, 16 (1), 43-48. doi: 10.1002/1098-1004(200007)16:1<43::AID-HUMU8>3.0.CO;2-7

Thomas, Gordon R., Costelloe, E. A., Lunn, D. P., Stacey, K. J., Passey, R., McGlinn, E. C., McMorran, B. J., Ahadizadeh, A., Geczy, C. L., Wainwright, B. J. and Hume, D. A. (2000). G551D cystic fibrosis mice exhibit abnormal regulation of inflammation in lungs and macrophages. The Journal of Immunology, 164 (7), 3870-3877. doi: 10.4049/jimmunol.164.7.3870

Wilson, PJ, McGlinn, E, Marsh, A, Evans, T, Arnold, J, Wright, K, Biden, K, Young, J, Wainwright, B, Wicking, C and Chenevix-Trench, G (2000). Sequence variants of DLC1 in colorectal ovarian tumours. Human Mutation, 15 (2), 156-165. doi: 10.1002/(SICI)1098-1004(200002)15:2

Smyth, I., Narang, M. A., Evans, T. M., Heimann, C., Nakamura, Y., Chenevix-Trench, G., Pietsch, T., Wicking, C. A. and Wainwright, B. J. (1999). Isolation and characterization of human patched 2 (PTCH2), a putative tumour suppressor gene in basal cell carcinoma and medulloblastoma on chromosome 1p32. Human Molecular Genetics, 8 (2), 291-297. doi: 10.1093/hmg/8.2.291

Smith, Stephen N., Middleton, Peter G., Chadwick, Sharon, Jaffe, Adam, Bush, Katy A., Rolleston, Sarah, Farley, Ray, Delaney, Stephen J., Wainwright, Brandon, Geddes, Duncan M. and Alton, Eric W. F. W. (1999). The in vivo effects of milrinone on the airways of cystic fibrosis mice and human subjects. American Journal of Respiratory Cell and Molecular Biology, 20 (1), 129-134. doi: 10.1165/ajrcmb.20.1.3278

Smyth, I, Bowles, J, Rothnagel, J, Wicking, C and Wainwright, B (1999). Ectopic expression of Sonic Hedgehog from the human Keratin 1 promoter gives rise to limb abnormalities and skin lesions in transgenic mice.. American Journal of Human Genetics, 65 (4), A371-A371.

Lansdell, K. A., Kidd, J. F., Delaney, S. J., Wainwright, B. J. and Sheppard, D. N. (1998). Regulation of murine cystic fibrosis transmembrane conductance regulator Cl- channels expressed in Chinese hamster ovary cells. Journal of Physiology, 512 (3), 751-764. doi: 10.1111/j.1469-7793.1998.751bd.x

Shaw, JTE, Lovelock, PK, Kesting, JB, Cardinal, J, Duffy, D, Wainwright, B and Cameron, DP (1998). Novel susceptibility gene for late-onset NIDDM is localized to human chromosome 12q. Diabetes, 47 (11), 1793-1796. doi: 10.2337/diabetes.47.11.1793

Wicking, C, Simms, LA, Evans, T, Walsh, M, Chawengsaksophak, K, Beck, F, Chenevix-Trench, G, Young, J, Jass, J, Leggett, B and Wainwright, B (1998). CDX2, a human homologue of Drosophila caudal, is mutated in both alleles in a replication error positive colorectal cancer. Oncogene, 17 (5), 657-659. doi: 10.1038/sj.onc.1201971

Smyth, , Wicking, C, Wainwright, B and Chenevix-Trench, G (1998). The effects of splice site mutations in patients with naevoid basal cell carcinoma syndrome. Human Genetics, 102 (5), 598-601. doi: 10.1007/s004390050747

Lansdell, K. A., Delaney, S. J., Lunn, D. P., Thomson, S. A., Sheppard, D. N. and Wainwright, B. J. (1998). Comparison of the gating behaviour of human and murine cystic fibrosis transmembrane conductance regulator Cl- channels expressed in mammalian cells. Journal of Physiology, 508 (2), 379-392. doi: 10.1111/j.1469-7793.1998.379bq.x

Wicking, C, Evans, T, Henk, B, Hayward, N, Simms, LA, Chenevix-Trench, G, Pietsch, T and Wainwright, B (1998). No evidence for the H133Y mutation in SONIC HEDGEHOG in a collection of common tumour types. Oncogene, 16 (8), 1091-1093. doi: 10.1038/sj.onc.1201644

Smith, Stephen N., Delaney, Stephen J., Dorin, Julia R., Farley, Raymond, Geddes, Duncan M., Porteous, David J., Wainwright, Brandon J. and Alton, Eric W. F. W. (1998). Effect of IBMX and alkaline phosphatase inhibitors on Cl- secretion in G551D cystic fibrosis mutant mice. American Journal of Physiology - Cell Physiology, 274 (2 43-2). doi: 10.1152/ajpcell.1998.274.2.c492

Richards, Frances M., Goudie, David R., Cooper, Wendy N., Jene, Quitz, Barroso, Inês , Wicking, Carol, Wainwright, Brandon J. and Ferguson-Smith, Malcolm A. (1997). Mapping the multiple self-healing squamous epithelioma (MSSE) gene and investigation of xeroderma pigmentosum group A (XPA) and PATCHED (PTCH) as candidate genes. Human Genetics, 101 (3), 317-322. doi: 10.1007/s004390050635

Lench, NJ, Telford, EAR, High, AS, Markham, AF, Wicking, C and Wainwright, BJ (1997). Characterisation of human patched germ line mutations in naevoid basal cell carcinoma syndrome. Human Genetics, 100 (5-6), 497-502. doi: 10.1007/s004390050541

Pietsch, T, Waha, A, Koch, A, Kraus, J, Albrecht, S, Tonn, J, Sorensen, N, Berthold, F, Henk, B, Schmandt, N, Wolf, HK, vonDeimling, A, Wainwright, B, ChenevixTrench, G, Wiestler, OD and Wicking, C (1997). Medulloblastomas of the desmoplastic variant carry mutations of the human homologue of Drosophila patched. Cancer Research, 57 (11), 2085-2088.

Shih, Yang-Chia, Kerr, Judith, Liu, Jim, Hurst, Terry, Khoo, Soo-Keat, Ward, Bruce, Wainwright, Brandon and Chenevix-Trench, Georgia (1997). Rare mutations and no hypermethylation at the CDKN2A locus in epithelial ovarian tumours. International Journal of Cancer, 70 (5), 508-511. doi: 10.1002/(SICI)1097-0215(19970304)70:5<508::AID-IJC3>3.0.CO;2-1

Holmes, G, Boterashvili, S, English, M, Wainwright, B, Licht, J and Little, M (1997). Two N-terminal self-association domains are required for the dominant negative transcriptional activity of WT1 Denys-Drash mutant proteins. Biochemical and Biophysical Research Communications, 233 (3), 723-728. doi: 10.1006/bbrc.1997.6545

Suzuki, K, Daigo, Y, Fukuda, S, Tokino, T, Isomura, M, Isono, K, Wainwright, B and Nakamura, Y (1997). No evidence of mutation in the human PTC gene, responsible for nevoid basal cell carcinoma syndrome, in human primary squamous cell carcinomas of the esophagus and lung. Japanese journal of cancer research : Gann, 88 (3), 225-8. doi: 10.1111/j.1349-7006.1997.tb00370.x

Levanat, S, Chidambaram, A, Wicking, C, BrayWard, P, Pressman, C, Toftgard, R, Gailani, MR, Myers, JC, Wainwright, B, Dean, M and Bale, AE (1997). Pulsed-field gel electrophoresis and FISH mapping of chromosome 9q22: Placement of a novel zinc finger gene within the NBCCS and ESS1 region. Cytogenetics and Cell Genetics, 76 (3-4), 208-213. doi: 10.1159/000134551

Wicking, Carol, Shanley, Susan, Smyth, Ian, Gillies, Susan, Negus, Kylie, Graham, Scott, Suthers, Graeme, Haites, Neva, Edwards, Matt, Wainwright, Brandon and Chenevix-Trench, Georgia (1997). Most germ-line mutations in the nevoid basal cell carcinoma syndrome lead to a premature termination of the PATCHED protein, and no genotype-phenotype correlations are evident. American Journal of Human Genetics, 60 (1), 21-26.

Wicking, C., Gillies, S., Smyth, I., Shanley, S., Fowles, L., Ratcliffe, J., Wainwright, B. and Chenevix-Trench, G. (1997). De novo mutations of the patched gene in nevoid basal cell carcinoma syndrome help to define the clinical phenotype. American Journal of Medical Genetics Part A, 73 (3), 304-307. doi: 10.1002/(SICI)1096-8628(19971219)73:3<304::AID-AJMG14>3.0.CO;2-N

Monkley, Susan J., Delaney, Stephen J., Pennisi, David J., Christiansen, Jeffrey H. and Wainwright, Brandon J. (1996). Targeted disruption of the Wnt2 gene results in placentation defects. Development, 122 (11), 3343-3353. doi: 10.1242/dev.122.11.3343

Dorin, J. R., Farley, R., Webb, S., Smith, S. N., Farini, E., Delaney, S. J., Wainwright, B. J., Alton, E. W.F.W. and Porteous, D. J. (1996). A demonstration using mouse models that successful gene therapy for cystic fibrosis requires only partial gene correction. Gene Therapy, 3 (9), 797-801.

Little, MH, Holmes, G, Pell, L, Caricasole, A, Duarte, A, Law, M, Ward, A and Wainwright, B (1996). A novel target for the Wilms' tumour suppressor protein (WT1) is bound by a unique combination of zinc fingers. Oncogene, 13 (7), 1461-1469.

Hahn, H, Wicking, C, Zaphiropoulos, PG, Gailani, MR, Shanley, S, Chidambaram, A, Vorechovsky, , Holmberg, E, Unden, AB, Gillies, S, Negus, K, Smyth, , Pressman, C, Leffell, DJ, Gerrard, B, Goldstein, AM, Dean, M, Toftgard, R, ChenevixTrench, G, Wainwright, B and Bale, AE (1996). Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell, 85 (6), 841-851. doi: 10.1016/S0092-8674(00)81268-4

Hahn, Heidi, Christiansen, Jeffrey, Wicking, Carol, Zaphiropoulos, Peter G., Chidambaram, Abirami, Gerrard, Bernard, Vorechovsky, Igor, Bale, Allen E., Toftgard, Rune, Dean, Michael and Wainwright, Brandon (1996). A mammalian patched homolog is expressed in target tissues of sonic hedgehog and maps to a region associated with developmental abnormalities. Journal of Biological Chemistry, 271 (21), 12125-12128. doi: 10.1074/jbc.271.21.12125

Delaney, Stephen J., Alton, Eric W.F.W., Smith, Stephen N., Lunn, Dominic P., Farley, Ray, Lovelock, Paul K., Thomson, Scott A., Hume, David A., Lamb, David, Porteous, David J., Dorin, Julia R. and Wainwright, Brandon J. (1996). Cystic fibrosis mice carrying the missense mutation G551D replicate human genotype-phenotype correlations. EMBO Journal, 15 (5), 955-963. doi: 10.1002/j.1460-2075.1996.tb00432.x

Christiansen J.H., Monkley S.J. and Wainwright B.J. (1996). Murine WNT11 is a secreted glycoprotein that morphologically transforms mammary epithelial cells. Oncogene, 12 (12), 2705-2711.

Delaney, Stephen J. and Wainwright, Brandon J. (1996). New pharmaceutical approaches to the treatment of cystic fibrosis. Gene therapy for cystic fibrosis is advancing rapidly but drug therapy is quickly catching up (pages 467-469). Nature Medicine, 2 (4), 392-393. doi: 10.1038/nm0496-392

Negus, K, Holmes, GH, Wicking, C, Wainwright, BJ and Little, MH (1996). +P5(D1S3309E), a novel target binding site for the Wilms' tumour suppressor 1 (WT1) gene, maps to human chromosome 1q21->q22. Cytogenetics and Cell Genetics, 72 (4), 306-309. doi: 10.1159/000134210

Little, M and Wainwright, B (1995). Methylation and P16 - Suppressing the Suppressor. Nature Medicine, 1 (7), 633-634. doi: 10.1038/nm0795-633

Christiansen, Jeffrey H., Dennis, Carina L., Wicking, Carol A., Monkley, Susan J., Wilkinson, David G. and Wainwright, Brandon J. (1995). Murine Wnt-11 and Wnt-12 have temporally and spatially restricted expression patterns during embryonic development. Mechanisms of Development, 51 (2-3), 341-350. doi: 10.1016/0925-4773(95)00383-5

Little, M, Holmes, G, Bickmore, W, Vanheyningen, V, Hastie, N and Wainwright, B (1995). Dna-Binding Capacity of the Wt1 Protein Is Abolished by Denys-Drash Syndrome Wt1 Point Mutations. Human Molecular Genetics, 4 (3), 351-358. doi: 10.1093/hmg/4.3.351

M.shanley, Susan, Dawkins, Hugh, J.wainwright, Brandon, Wicking, Carol, Heenan, Peter, Eldon, Michael, Searle, Jeffrey and Chenevlx-trench, Georgia (1995). Fine deletion mapping on the long arm of chromosome 9 in sporadic and familial basal cell carcinomas. Human Molecular Genetics, 4 (1), 129-133. doi: 10.1093/hmg/4.1.129

WICKING, C, BREEN, M, NEGUS, K, BERKMAN, J, EVDOKIOU, A, COWLED, P, CHENEVIXTRENCH, G and WAINWRIGHT, B (1995). THE HUMAN GROWTH-ARREST-SPECIFIC GENE GAS 1 MAPS OUTSIDE THE CANDIDATE REGION OF THE GENE FOR NEVOID BASAL-CELL CARCINOMA SYNDROME. Cytogenetics and Cell Genetics, 68 (1-2), 119-121. doi: 10.1159/000133904

Hume, D. A., Monkley, S. J. and Wainwright, B. J. (1995). Detection of c-fms protooncogene in early mouse embryos by whole mount in situ hybridization indicates roles for macrophages in tissue remodelling. British Journal of Haematology, 90 (4), 939-942. doi: 10.1111/j.1365-2141.1995.tb05220.x

Delaney, Stephen J., Koopman, Peter, Lovelock, Paul K. and Wainwright, Brandon J. (1994). Alternative splicing of the first nucleotide binding fold of CFTR in mouse testes is associated with specific stages of spermatogenesis. Genomics, 20 (3), 517-518. doi: 10.1006/geno.1994.1214

Wainwright B. (1994). Familial melanoma and p16 — A hung jury. Nature Genetics, 8 (1), 3-5. doi: 10.1038/ng0994-3

Berkman, Jenny, Armour, John A.L., Chenevix-trench, Georgia, Wicking, Carol and Wainwright, Brandon (1994). Simple repeat polymorphism at the D9S151 locus. Human Molecular Genetics, 3 (1), 211-211. doi: 10.1093/hmg/3.1.211

Adamson M.C., Dennis C., Delaney S., Christiansen J., Monkley S., Kozak C.A. and Wainwright B. (1994). Isolation and genetic mapping of two novel members of the murine Wnt gene family, Wnt11 and Wnt12, and the mapping of Wnt5a and Wnt7a. Genomics, 24 (1), 9-13. doi: 10.1006/geno.1994.1575

Wicking C., Berkman J., Wainwright B. and Chenevix-Trench G. (1994). Fine genetic mapping of the gene for nevoid basal cell carcinoma syndrome. Genomics, 22 (3), 505-511. doi: 10.1006/geno.1994.1423

Delaney, Stephen J., Rich, Devra P., Thomson, Scott A., Hargrave, Murray R., Lovelock, Paul K., Welsh, Michael J. and Wainwright, Brandon J. (1993). Cystic fibrosis transmembrane conductance regulator splice variants are not conserved and fail to produce chloride channels. Nature Genetics, 4 (4), 426-430. doi: 10.1038/ng0893-426

Wainwright, B. J. (1993). The isolation of disease genes by positional cloning. Medical Journal of Australia, 159 (3), 170-174. doi: 10.5694/j.1326-5377.1993.tb137781.x

Siegel, D., Irving, N. G., Friedman, J. M. and Wainwright, B. J. (1992). Localization of the cystic fibrosis transmembrane conductance regulator (Cftr) to mouse chromosome 6. Cytogenetic and Genome Research, 61 (3), 184-185. doi: 10.1159/000133404

Don R.H., Cox P.T., Wainwright B.J., Baker K. and Mattick J.S. (1991). 'Touchdown' PCR to circumvent spurious priming during gene amplification. Nucleic Acids Research, 19 (14), 4008. doi: 10.1093/nar/19.14.4008

Wainwright, B. (1991). The molecular pathology of cystic fibrosis. Current Biology, 1 (2), 80-82. doi: 10.1016/0960-9822(91)90283-3

R.Hope R.HopeRoryR.Hope R.HopeRoryhttps://api.elsevier.com/content/author/author_id/7102539044 (1989). Globin macromolecular sequences in marsupials and monotremes. Australian Journal of Zoology, 37 (3), 289-313. doi: 10.1071/ZO9890289

Conference Papers

Vo, Tuan, Balderson, Brad, Jones, Kahli, Crawford, Joanna, Millar, Amanda, Tolson, Elissa, Ruitenberg, Marc, Robertson, Thomas, Bhuva, Dharmesh, Davis, Melissa, Wainwright, Brandon, Nguyen, Quan and Genovesi, Laura (2022). MEDB-06. Spatial transcriptomic analysis of Sonic Hedgehog Medulloblastoma identifies that loss of heterogeneity and induced differentiation underlies the response to CDK4/6 inhibition. International Symposium on Pediatric Neuro-Oncology, Hamburg, Germany, 12–15 June 2022. Cary, NC, United States: Oxford University Press. doi: 10.1093/neuonc/noac079.381

Villani, R., Sim, S. L., Greaney, J., Wainwright, B. and Khosrotehrani, K. (2016). Basal cell carcinoma development is promoted by ablation of the dermal papilla mesenchymal niche. Asia-Pacific Combined Dermatology Research Conference 2016, Noosa, QLD, Australia, 25–28 August 2016. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/ajd.12584

Ji, Pengxiang, Genovesi, Laura, He, Yaowu, Hooper, John and Wainwright, Brandon (2016). Targeting Apoptosis as a Novel Therapy for Myc-Driven Medulloblastoma. 17th International Symposium on Pediatric Neuro-Oncology (ISPNO), Liverpool England, 12-15 June 2016. United States: Oxford University Press.

Villani, R. M., Hodgson, S., Legrand, J., Greaney, J., Wong, H., Pichol-Thievend, C., Adolphe, C., Wainwright, B., Francois, M. and Khosrotehrani, K. (2015). Dominant negative mutation of Sox18 inhibits normal dermal papilla development during embryogenesis and regeneration. 45th Annual Meeting of the European Society for Dermatological Research, Rotterdam, Netherlands, 9-12 September 2015. London, United Kingdom: Nature Publishing Group. doi: 10.1038/jid.2015.272

Genovesi, Laura, Ji, Pengxiang, Davis, Melissa, Ching Ging Ng, Remke, Marc, Taylor, Michael, Cho, Yoon-Jae, Jenkins, Nancy, Copeland, Neil and Wainwright, Brandon (2014). Mouse Functional Genomics to Predict Novel Drug Targets for All Subgroups of Medulloblastoma. 16th International Symposium on Pediatric Neuro-Oncology (ISPNO), Singapore, Singapore, 28 June - 02 July 2014. Cary, NC United States: Oxford University Press. doi: 10.1093/neuonc/nou074

Adolphe, C., Villani, R., Niewenhuis, E., Li, S., Kaur, P., Hui, C. and Wainwright, B. (2012). Hedgehog pathway regulation of basal cell carcinoma and epidermal differentiation. Conjoint 3rd Australasian Wound & Tissue Repair Society and 9th Australasian Society for Dermatology Research Conference, Sydney, NSW, Australia, 22-24 May 2012. Hoboken, NJ, United States: Wiley-Blackwell. doi: 10.1111/j.1524-475X.2012.00835.x

Metzis, Vicki, Courtney, Andrew, Ferguson, Charles, Cooper, Ashley, Wainwright, Brandon and Wicking, Carol (2011). Patched1 is essential for nasal pit invagination in mouse. Society for Developmental Biology 70th Annual Meeting, Chicago IL, United States, 21-25 July 2011. Maryland Heights MO, United States: Academic Press. doi: 10.1016/j.ydbio.2011.05.164

Haase, E, Hallahan, A and Wainwright, B (2009). The interaction of Sonic Hedgehog and Notch signalling in medulloblastoma. 16th Annual Conference of the International-Society-of-Development-Biologists, Edinburgh Scotland, Sep 06-10, 2009. AMSTERDAM: ELSEVIER SCIENCE BV. doi: 10.1016/j.mod.2009.06.496

Brewster, Brooke, Brooks, Kelly, Brown, Melissa Anne, Clarke, C., Fleming, J. S., French, J. D., Hetherington, Rehan, Lakhani, Sunil, Raghavendra, Ashwini, Rothnagel, Joseph, Smart, Chanel and Wainwright, Brandon (2007). Targeted disruption of Brca1 in restricted compartments of the mouse mammary epithelia. Gordon Research Conference: Mammary Gland Biology, Newport, RI, 10-15 June 2007.

Brewster, Brooke, Brooke, Kelly, Brown, Melissa Anne, Clarke, C., Fleming, J. S., French, J. D., Hetherington, Rehan, Lakhani, Sunil, Raghavendra, Ashwini, Rothnagel, Joseph, Smart, Chanel and Wainwright, Brandon (2007). Targeted disruption of Brca1 in restricted compartments of the mouse mammary epithelia. kConFab Familial Breast Cancer Conference, Couran Cove, Queensland, 21-24 August 2007.

Smart, C. E., Clarke, C., Brooks, K. M., Raghavendra, A., Brewster, B. L., French, J. D., Hetherington, R., Fleming, J. S., Rothnagel, J. A., Wainwright, B., Lakhani, S. R. and Brown, M. A. (2007). Targeted disruption of Brca1 in restricted compartments of the mouse mammary epithelia. Australian Breast Cancer Conference, Melbourne, Australia, 2007.

Smid, J. R., Young, W. G., McMorran, B. J. and Wainwright, B. J. (2006). Iron metabolism in G551D cystic fibrosis mouse incisor ameloblasts. IADR ANZ Division 38th Annual Scientific Meeting, Brisbane, Qld, Australia, 28 June - 1 July, 2006. Chicago, Ill. U.S.A: Sage for the American Dental Association.

Armstrong, D., Byrnes, C., Carlin, J., Cooper, P., Francis, P., Grimwood, K., Jones, A., McMorran, B., Robertson, C., Wainwright, B. and Wainwright, C. (2005). Proteomic investigations in the young CF lung: new insights into the inflammatory disorder. 6th Australian and New Zealand Cystic Fibrosis Conference 2005, Adelaide, South Australia, 20-23 August, 2005.

Ellis, T., Bourboulas, M., Bull, N. D., Bartlett, P. F. and Wainwright, B. J. (2005). Patched ablation in neuronal precursors leads to defects in CNS patterning and abnormal regulation of the neuronal stem cell population. 15th International Society of Developmental Biologists Congress, Sydney, NSW, Australia, 3-7 September 2005. Shannon, Co. Clare, Ireland: Elsevier. doi: 10.1016/j.mod.2005.06.010

Wicking, C. A., Evans, T., Wainwright, B. and Parton, R. (2001). Insights into the regulation of hedgehog signalling from subcellular localisation studies. -, -, -. Chicago, IL United States: University of Chicago Press.

Shaw, JTE, Lovelock, PK, Duffy, D, Cardinal, J, Berkholz, JR, Kesting, JB and Wainwright, B (1998). Novel susceptibility gene for NIDDM is localised to human chromosome 12q. NEW YORK: SPRINGER VERLAG.